Computational Biology, Gene Transcription Regulation

    In tumor cells, genetic mutations can affect key factors that regulate gene expression, such as transcription factors and transcription mediators. This can disrupt the normal gene regulatory network, leading to uncontrolled growth regulation in normal cells and resulting in the unlimited proliferation, invasion, and metastasis of tumor cells. Understanding the unique transcriptional regulatory mechanisms of tumor cells can help identify potential therapeutic targets and develop targeted anti-cancer treatments.
    Our laboratory conducts computational biology research on key issues related to gene expression in tumors, focusing on the following areas:

• The mechanism by which special transcription factors promote tumorigenesis in tumors.
• The relationship between genomic repeat sequences and tumorigenesis.
• The regulation of gene expression at the cellular subpopulation level and spatial transcriptome level in tumor cells.